2586047-09-6

2586047-09-6 structure

Name: CDN-A
Chemical Name: CDN-A
CAS Number: 2586047-09-6
Molecular Formula: C₂₂H₂₉N₁₁O₁₂P₂
Molecular Weight: 701.48
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2023-01-27 01:58:25
Modify Date: 2024-04-05 20:10:38
CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes[1][2][3].

Name	CDN-A

Description	CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> STING
References	[1]. Chen, Zhijian, et al. Antinbody-sting agonist conjugates and their use in immunotherapy. US 2021/0015941 Al. 2021. [2]. Lirussi D, et al. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway. EBioMedicine. 2017 Aug;22:100-111. [3]. Schaap P. Cyclic di-nucleotide signaling enters the eukaryote domain. IUBMB Life. 2013 Nov;65(11):897-903.

Molecular Formula	C₂₂H₂₉N₁₁O₁₂P₂
Molecular Weight	701.48