946415-13-0

946415-13-0 structure

946415-13-0 structure

Name: FG-3019
Chemical Name: FG-3019
CAS Number: 946415-13-0
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-02-13 08:58:59
Modify Date: 2024-01-03 17:21:10
FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].

Name	FG-3019

Description	FG-3019 (Pamrevlumab) is a recombinant human antibody that binds to connective tissue growth factor (CTGF). FG-3019 can be used for the research of idiopathic pulmonary fibrosis (IPF)[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vivo	FG-3019 (30 mg/kg; i.p. every 3 d for 9 d) 与 Gemcitabine 联合使用可显着降低小鼠胰腺导管腺癌 (PDA) 的生长，并诱导 LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) 小鼠中的肿瘤细胞凋亡[2]。
References	[1]. Sgalla G, et, al. Pamrevlumab for the treatment of idiopathic pulmonary fibrosis. Expert Opin Investig Drugs. 2020 Aug;29(8):771-777. [2]. Neesse A, et, al. CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer. Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12325-30.

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