141636-44-4

141636-44-4 structure

141636-44-4 structure

Name: GR 83074
Chemical Name: GR 83074
CAS Number: 141636-44-4
Molecular Formula: C₅₀H₇₂N₁₂O₉
Molecular Weight: 985.18
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2023-01-11 22:49:35
Modify Date: 2024-04-05 14:28:50
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity[1].

Name	GR 83074

Description	GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
In Vitro	在离体大鼠结肠和豚鼠气管中，GR 83074 是选择性 NK-2 激动剂 GR6434 诱导的收缩的有效竞争性拮抗剂[1]。
In Vivo	对麻醉的人工呼吸豚鼠静脉注射 GR 83074 (compound 10) (0.3 μmol/kg) 可显着拮抗 NK-2 激动剂 GR64349 引起的气管充气压力增加[1]。
References	[1]. A B McElroy, et al. Highly potent and selective heptapeptide antagonists of the neurokinin NK-2 receptor. J Med Chem. 1992 Jul 10;35(14):2582-91.

Molecular Formula	C₅₀H₇₂N₁₂O₉
Molecular Weight	985.18