GR 83074 structure
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Common Name | GR 83074 | ||
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CAS Number | 141636-44-4 | Molecular Weight | 985.18 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C50H72N12O9 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of GR 83074GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity[1]. |
Name | GR 83074 |
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Description | GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pKB of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity[1]. |
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Related Catalog | |
In Vitro | 在离体大鼠结肠和豚鼠气管中,GR 83074 是选择性 NK-2 激动剂 GR6434 诱导的收缩的有效竞争性拮抗剂[1]。 |
In Vivo | 对麻醉的人工呼吸豚鼠静脉注射 GR 83074 (compound 10) (0.3 μmol/kg) 可显着拮抗 NK-2 激动剂 GR64349 引起的气管充气压力增加[1]。 |
References |
Molecular Formula | C50H72N12O9 |
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Molecular Weight | 985.18 |