2849340-59-4
2849340-59-4 structure
- Name: p53 Activator 7
- Chemical Name: p53 Activator 7
- CAS Number: 2849340-59-4
- Molecular Formula: C27H32F3N4OP
- Molecular Weight: 516.54
- Catalog: Signaling Pathways Apoptosis MDM-2/p53
- Create Date: 2023-01-17 18:10:03
- Modify Date: 2024-04-08 19:29:48
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p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)[1].
| Name | p53 Activator 7 |
|---|
| Description | p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 104 nM (p53 mutation Y220C)[1] |
| In Vitro | The p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus[1]. |
| References |
[1]. Sujing LI, et al. Compounds targeting y220c mutant of p53. WO2022213975A1. |
| Molecular Formula | C27H32F3N4OP |
|---|---|
| Molecular Weight | 516.54 |