p53 Activator 7

Modify Date: 2024-04-08 19:29:48

p53 Activator 7 structure	Common Name	p53 Activator 7
	CAS Number	2849340-59-4	Molecular Weight	516.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₂F₃N₄OP	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of p53 Activator 7

p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)[1].

Name	p53 Activator 7

Description	p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
Target	EC50: 104 nM (p53 mutation Y220C)[1]
In Vitro	The p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus[1].
References	[1]. Sujing LI, et al. Compounds targeting y220c mutant of p53. WO2022213975A1.

Molecular Formula	C₂₇H₃₂F₃N₄OP
Molecular Weight	516.54