1196994-12-3
1196994-12-3 structure
- Name: ST-1006 Maleate
- Chemical Name: ST-1006 Maleate
- CAS Number: 1196994-12-3
- Molecular Formula: C24H28Cl2N6O8
- Molecular Weight: 599.42
- Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
- Create Date: 2023-01-29 23:24:04
- Modify Date: 2024-04-09 17:46:38
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ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect[1][2].
| Name | ST-1006 Maleate |
|---|
| Description | ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils[2]. ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2]. |
| In Vivo | ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect[1]. Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg. |
| References |
| Molecular Formula | C24H28Cl2N6O8 |
|---|---|
| Molecular Weight | 599.42 |