1196994-12-3

1196994-12-3 structure

1196994-12-3 structure

Name: ST-1006 Maleate
Chemical Name: ST-1006 Maleate
CAS Number: 1196994-12-3
Molecular Formula: C₂₄H₂₈Cl₂N₆O₈
Molecular Weight: 599.42
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2023-01-29 23:24:04
Modify Date: 2024-04-09 17:46:38
ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect[1][2].

Name	ST-1006 Maleate

Description	ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils[2]. ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].
In Vivo	ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect[1]. Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1] Dosage: 1-100 mg/kg Administration: Subcutaneous injection Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
References	[1]. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397. [2]. Mommert S, et, al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016 Sep;71(9):1264-73.

Molecular Formula	C₂₄H₂₈Cl₂N₆O₈
Molecular Weight	599.42