1628224-94-1
1628224-94-1 structure
- Name: Thrombin inhibitor 6
- Chemical Name: Thrombin inhibitor 6
- CAS Number: 1628224-94-1
- Molecular Formula: C18H19ClN4O2S
- Molecular Weight: 390.89
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
- Create Date: 2023-01-15 08:42:00
- Modify Date: 2024-04-03 11:18:16
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Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].
| Name | Thrombin inhibitor 6 |
|---|
| Description | Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Thrombin inhibitor 6 (compound 73) 在与 CD-1 小鼠和人微粒体孵育时是稳定的 (Clint (小鼠) = 60 μL/min/mg；Clint (人) = 17 μL/min/mg)[1]. |
| In Vivo | Thrombin inhibitor 6 (compound 73) (9 mg/kg，静脉注射) 可延长 CD-1 小鼠的尾部出血时间[1]。 Thrombin inhibitor 6 (compound 73) (5 mg/kg，口服) 在雄性 CD-1 小鼠中的 F(%) 为 22.8%，AUC 为 713.3 h.ng/mL，Cmax 为 127 ng/mL[1]。 Animal Model: CD-1 mice[1] Dosage: 9 mg/kg Administration: Intravenous injection (i.v.) Result: The mice bled for 25 min following transection. Led to 1.5-fold increase of liberated whole blood cells. |
| References |
| Molecular Formula | C18H19ClN4O2S |
|---|---|
| Molecular Weight | 390.89 |