1628224-94-1

1628224-94-1 structure

1628224-94-1 structure

Name: Thrombin inhibitor 6
Chemical Name: Thrombin inhibitor 6
CAS Number: 1628224-94-1
Molecular Formula: C₁₈H₁₉ClN₄O₂S
Molecular Weight: 390.89
Catalog: Signaling Pathways Metabolic Enzyme/Protease Thrombin
Create Date: 2023-01-15 08:42:00
Modify Date: 2024-04-03 11:18:16
Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].

Name	Thrombin inhibitor 6

Description	Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin
In Vitro	Thrombin inhibitor 6 (compound 73) 在与 CD-1 小鼠和人微粒体孵育时是稳定的 (Clint (小鼠) = 60 μL/min/mg；Clint (人) = 17 μL/min/mg)[1].
In Vivo	Thrombin inhibitor 6 (compound 73) (9 mg/kg，静脉注射) 可延长 CD-1 小鼠的尾部出血时间[1]。 Thrombin inhibitor 6 (compound 73) (5 mg/kg，口服) 在雄性 CD-1 小鼠中的 F(%) 为 22.8%，AUC 为 713.3 h.ng/mL，Cmax 为 127 ng/mL[1]。 Animal Model: CD-1 mice[1] Dosage: 9 mg/kg Administration: Intravenous injection (i.v.) Result: The mice bled for 25 min following transection. Led to 1.5-fold increase of liberated whole blood cells.
References	[1]. Short KM, et al. Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors. Eur J Med Chem. 2022 Oct 27;246:114855.

Molecular Formula	C₁₈H₁₉ClN₄O₂S
Molecular Weight	390.89