Thrombin inhibitor 6

Modify Date: 2024-04-03 11:18:16

Thrombin inhibitor 6 Structure
Thrombin inhibitor 6 structure
Common Name Thrombin inhibitor 6
CAS Number 1628224-94-1 Molecular Weight 390.89
Density N/A Boiling Point N/A
Molecular Formula C18H19ClN4O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thrombin inhibitor 6


Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].

 Names

Name Thrombin inhibitor 6

 Thrombin inhibitor 6 Biological Activity

Description Thrombin inhibitor 6 is a potent thrombin inhibitor (IC50: 1 nM). Thrombin inhibitor 6 has the function as an anticoagulant[1].
Related Catalog
In Vitro Thrombin inhibitor 6 (compound 73) 在与 CD-1 小鼠和人微粒体孵育时是稳定的 (Clint (小鼠) = 60 μL/min/mg;Clint (人) = 17 μL/min/mg)[1].
In Vivo Thrombin inhibitor 6 (compound 73) (9 mg/kg,静脉注射) 可延长 CD-1 小鼠的尾部出血时间[1]。 Thrombin inhibitor 6 (compound 73) (5 mg/kg,口服) 在雄性 CD-1 小鼠中的 F(%) 为 22.8%,AUC 为 713.3 h.ng/mL,Cmax 为 127 ng/mL[1]。 Animal Model: CD-1 mice[1] Dosage: 9 mg/kg Administration: Intravenous injection (i.v.) Result: The mice bled for 25 min following transection. Led to 1.5-fold increase of liberated whole blood cells.
References

[1]. Short KM, et al. Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors. Eur J Med Chem. 2022 Oct 27;246:114855.  

 Chemical & Physical Properties

Molecular Formula C18H19ClN4O2S
Molecular Weight 390.89