1135688-25-3
1135688-25-3 structure
- Name: Z-LEVD-FMK
- Chemical Name: Z-LEVD-FMK
- CAS Number: 1135688-25-3
- Molecular Formula: C31H45FN4O10
- Molecular Weight: 652.71
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-01-14 12:59:07
- Modify Date: 2025-08-26 18:40:52
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Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1].
| Name | Z-LEVD-FMK |
|---|
| Description | Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1]. |
|---|---|
| Related Catalog | |
| Target |
Caspase-4 |
| In Vitro | Z-LEVD-FMK (2 ng/mL, 30 min) blocks IL-1β-induced IL-8 production in hRPE cells[1]. Z-LEVD-FMK (2 μM) inhibits caspase-3 activity in hRPE cells[1]. Z-LEVD-FMK (20 μM, 96 h) completely blocks E2-induced PARP cleavage in 5C cells[2]. Z-LEVD-FMK (20 μM, 96 h) reverses E2-inhibited growth and prevents morphologic alterations associated with apoptosis in 5C cells[2]. Western Blot Analysis[1] Cell Line: hRPE cells (treated with IL-1β of 2 ng/mL for additional 24 h) Concentration: 2 ng/mL Incubation Time: 30 min Result: Inhibited IL-1β-induced IL-8 production. |
| References |
| Molecular Formula | C31H45FN4O10 |
|---|---|
| Molecular Weight | 652.71 |