Z-LEVD-FMK structure
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Common Name | Z-LEVD-FMK | ||
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CAS Number | 1135688-25-3 | Molecular Weight | 652.71 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C31H45FN4O10 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Z-LEVD-FMKZ-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1]. |
Name | Z-LEVD-FMK |
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Description | Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1]. |
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Related Catalog | |
Target |
Caspase-4 |
In Vitro | Z-LEVD-FMK (2 ng/mL, 30 min) blocks IL-1β-induced IL-8 production in hRPE cells[1]. Z-LEVD-FMK (2 μM) inhibits caspase-3 activity in hRPE cells[1]. Z-LEVD-FMK (20 μM, 96 h) completely blocks E2-induced PARP cleavage in 5C cells[2]. Z-LEVD-FMK (20 μM, 96 h) reverses E2-inhibited growth and prevents morphologic alterations associated with apoptosis in 5C cells[2]. Western Blot Analysis[1] Cell Line: hRPE cells (treated with IL-1β of 2 ng/mL for additional 24 h) Concentration: 2 ng/mL Incubation Time: 30 min Result: Inhibited IL-1β-induced IL-8 production. |
References |
Molecular Formula | C31H45FN4O10 |
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Molecular Weight | 652.71 |