1017857-38-3

1017857-38-3 structure

Name: β2AR/M-receptor agonist-2
Chemical Name: β2AR/M-receptor agonist-2
CAS Number: 1017857-38-3
Molecular Formula: C₃₆H₄₉ClN₄O₇S
Molecular Weight: 717.31
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2023-01-19 15:36:45
Modify Date: 2024-01-03 08:00:30
β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1].

Name	β2AR/M-receptor agonist-2

Description	β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vivo	β2AR/M-receptor agonist-2 剂量依赖地抑制甲基胆碱诱导的犬支气管收缩，其 ID50 值为 50 mg[1]。
References	[1]. Laura Hilton, et al. Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD. MedChemComm. 2011.

Molecular Formula	C₃₆H₄₉ClN₄O₇S
Molecular Weight	717.31