960358-79-6
960358-79-6 structure
- Name: CKLF1-C19
- Chemical Name: CKLF1-C19
- CAS Number: 960358-79-6
- Molecular Formula: C103H161N27O28
- Molecular Weight: 2225.54
- Catalog: Signaling Pathways GPCR/G Protein CCR
- Create Date: 2023-02-19 20:55:35
- Modify Date: 2024-04-06 12:13:30
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CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4[1].
| Name | CKLF1-C19 |
|---|
| Description | CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4[1]. |
|---|---|
| Related Catalog | |
| Target |
CCL17-CCR4 CCR3 |
| In Vitro | CKLF1-C19 (200 ng/mL 或 500 ng/mL; 30 分钟) 诱导人类 Th2 细胞的趋化迁移[1]。 CKLF1-C19 (100 ng/mL; 30 分钟) 抑制 CCL-11 诱导的小鼠嗜酸性粒细胞和人 CCR3 转染或小鼠 CCR3 转染的 HEK293 细胞的趋化性[1]。 |
| In Vivo | CKLF1-C19 (0.01-100 μg, 200 μL; 腹腔注射; 单次剂量, 注射于第 24-26 天, 在 OVA 诱导前 30 min) 导致卵清蛋白 (OVA) 组处理组的气道高反应性 (AHR) 显著低于生理盐水对照组[1]。 CKLF1-C19 (0.5 mg 或 1mg, 200 μL; 皮下注射; 单次剂量) 在哮喘小鼠模型中减少 CCL11 介导的嗜酸性粒细胞进入腹腔[1]。 |
| References |
| Molecular Formula | C103H161N27O28 |
|---|---|
| Molecular Weight | 2225.54 |