2685779-55-7
2685779-55-7 structure
- Name: CYP1B1-IN-4
- Chemical Name: CYP1B1-IN-4
- CAS Number: 2685779-55-7
- Molecular Formula: C18H14N2O2S
- Molecular Weight: 322.38
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
- Create Date: 2023-02-06 16:11:37
- Modify Date: 2024-01-20 20:23:15
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CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].
| Name | CYP1B1-IN-4 |
|---|
| Description | CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1]. |
|---|---|
| Related Catalog | |
| Target |
CYP1B1:0.2 nM (IC50) CYP1A1:3.98 μM (IC50) |
| In Vitro | CYP1B1-IN-4 (化合物15) (100 μM; 37 ℃; 0-60 min) 在人和大鼠肝微粒体中均具有体外稳定性，而在小鼠肝微粒体中稳定性较低[1]。 CYP1B1-IN-4 (1 nM-10 μM) 抑制 CYP1A1, IC50 为 3.82 μM[1]。 Cyp1b1-IN-4 (100 μM; 72 h) 对 HEK293 细胞无细胞毒性[1]。 |
| References |
| Molecular Formula | C18H14N2O2S |
|---|---|
| Molecular Weight | 322.38 |