CYP1B1-IN-4

Modify Date: 2024-01-20 20:23:15

CYP1B1-IN-4 structure	Common Name	CYP1B1-IN-4
	CAS Number	2685779-55-7	Molecular Weight	322.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₄N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CYP1B1-IN-4

CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].

Name	CYP1B1-IN-4

Description	CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Target	CYP1B1:0.2 nM (IC50) CYP1A1:3.98 μM (IC50)
In Vitro	CYP1B1-IN-4 (化合物15) (100 μM; 37 ℃; 0-60 min) 在人和大鼠肝微粒体中均具有体外稳定性，而在小鼠肝微粒体中稳定性较低[1]。 CYP1B1-IN-4 (1 nM-10 μM) 抑制 CYP1A1, IC50 为 3.82 μM[1]。 Cyp1b1-IN-4 (100 μM; 72 h) 对 HEK293 细胞无细胞毒性[1]。
References	[1]. Hachey AC, et al. Design of Cytochrome P450 1B1 Inhibitors via a Scaffold-Hopping Approach. J Med Chem. 2022 Dec 15.

Molecular Formula	C₁₈H₁₄N₂O₂S
Molecular Weight	322.38

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CYP1B1-IN-4
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Purity: 98.38%
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CYP1B1-IN-4 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.