2789629-84-9
2789629-84-9 structure
- Name: DCZ19931
- Chemical Name: DCZ19931
- CAS Number: 2789629-84-9
- Molecular Formula: C26H20F5N3O5
- Molecular Weight: 549.45
- Catalog: Signaling Pathways MAPK/ERK Pathway ERK
- Create Date: 2023-01-25 21:54:58
- Modify Date: 2024-04-03 09:23:20
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DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling[1].
| Name | DCZ19931 |
|---|
| Description | DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling[1]. |
|---|---|
| Related Catalog | |
| Target |
ERK1 ERK2 p38 MAPK |
| In Vitro | DCZ19931 (1 nM-10 μM; 24 h) 对人脐静脉内皮细胞 (HUVECs) 无明显的细胞毒性[1]。 DCZ19931 (500 nM; 24 h) 抑制 (10 ng/mL; 12 h) VEGFs 诱导的内皮细胞增殖、迁移和成管能力[1]。 DCZ19931 (500 nM; 24 h) 通过下调 ICAM-1，表达抑制血管通透性[1]。 DCZ19931 (500 nM; 24 h) 降低 HUVECs 中 p-ERK1/2、p-p38 和 p-JNK 的表达水平[1]。 DCZ19931 在小鼠脉络膜发芽试验中也显示出抗血管生成作用[1]。 Western Blot Analysis[1] Cell Line: Human umbilical vein endothelial cells (HUVECs) Concentration: 500 nM; with or without 50 ng/mL VEGF for 30 min Incubation Time: 24 hours Result: Decreased expression of phosphorylated ERK and phosphorylated p38. |
| In Vivo | DCZ19931 (1 μL, 1 μg/μL; 静脉注射; 单剂量) 抑制小鼠氧诱导视网膜病变 (OIR) 模型眼新生血管生成[1]. DCZ19931 (2 μL, 1 μg/μL; 静脉注射; 7 d) 无组织毒性，并抑制激光诱导脉络膜新生血管 (CNV) 模型小鼠的眼部新生血管生成[1]。 Animal Model: Laser-induced choroidal neovascularization (CNV) model in mice[1] Dosage: 2 μL, 1 μg/μL Administration: Intravitreal injection; single dose, monitored for 7 d following laser photocoagulation Result: Did not cause marked histopathological changes in retinal structures. Decreased the areas of CNV lesions, showed anti-angiogenic effect in vivo. Animal Model: Oxygen-induced retinopathy (OIR) model in mice[1] Dosage: 1 μL, 1 μg/μL Administration: Intravitreal injection; single dose Result: Further showed anti-angiogenic effect in vivo, inhibited ocular neovascularization. |
| References |
| Molecular Formula | C26H20F5N3O5 |
|---|---|
| Molecular Weight | 549.45 |