1202404-23-6
1202404-23-6 structure
- Name: Neuroinflammatory-IN-3
- Chemical Name: Neuroinflammatory-IN-3
- CAS Number: 1202404-23-6
- Molecular Formula: C19H19ClO3
- Molecular Weight: 330.81
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2023-02-01 21:52:20
- Modify Date: 2024-01-10 00:48:50
-
Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization[1][2].
| Name | Neuroinflammatory-IN-3 |
|---|
| Description | Neuroinflammatory-IN-3, a tubulin inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Neuroinflammatory-IN-3（compound 1）在 10μM 浓度下抑制 BV-2 小胶质细胞中 LPS 介导的 NO 释放至 70%，IC50 为 5.22μM。Neuroinflammatory-IN-3 与微管蛋白的秋水仙碱结合域结合[1]。 Neuroinflammatory-IN-3（compound 1；72 小时）对 HeLa、U266、A549 和 MCF7 细胞系具有抗增殖作用，IC50 分别值为 450 nM、416 nM、381 nM 和 744 nM[2]。 Neuroinflammatory-IN-3（compound 1；1 μM；3-12 小时）以时间依赖性方式触发细胞周期停滞[2]。 Neuroinflammatory-IN-3（compound 1）以剂量依赖性方式抑制微管蛋白聚合[2]。 Cell Cycle Analysis[2] Cell Line: HeLa cells Concentration: 1 μM Incubation Time: 3 h, 6 h, 12 h Result: Triggered cell-cycle arrest. |
| References |
| Molecular Formula | C19H19ClO3 |
|---|---|
| Molecular Weight | 330.81 |