2366260-33-3

2366260-33-3 structure

Name: Tubulin inhibitor 11
Chemical Name: Tubulin inhibitor 11
CAS Number: 2366260-33-3
Molecular Formula: C₂₂H₂₃N₃O₃S
Molecular Weight: 409.50
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-02-28 15:24:59
Modify Date: 2024-09-12 18:42:11
Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis[1].

Name	Tubulin inhibitor 11

Description	Tubulin inhibitor 11 is a potent and orally active tubulin inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Tubulin inhibitor 11 (Compound 48; 0.03-0.1 μM; 12 hours) causes cell cycle arrest at G2/M phase. Tubulin inhibitor 11 reduces cdc2 phosphorylation and increases cyclin B1 and phosphorylation of histone H3 at Ser10 in cells[1]. Tubulin inhibitor 11 (Compound 48; 0.03-0.3 μM; 48 hours) causes cancer cell apoptosis[1]. Tubulin inhibitor 11 (Compound 48) demonstrates favorable antiproliferative activities in DU145 cells with an IC50 of 8 nM[1]. Tubulin inhibitor 11 (Compound 48; 0.03-0.3 μM) significantly reduces the expression levels of acetyl-α-tubulin and α-tubulin in a dose-dependent manner[1]. Cell Cycle Analysis[1] Cell Line: DU145 cells Concentration: 0.01 μM, 0.03 μM, and 0.1 μM Incubation Time: 12 hours Result: Caused cell cycle arrest at G2/M phase. Apoptosis Analysis[1] Cell Line: DU145 cells Concentration: 0.03 μM, 0.1 μM, and 0.3 μM Incubation Time: 48 hours Result: Induced cancer cell apoptosis. Western Blot Analysis[1] Cell Line: DU145 cells Concentration: 0.01 μM, 0.03 μM, and 0.1 μM Incubation Time: 12 hours Result: Reduced cdc2 phosphorylation and increased cyclin B1 and phosphorylation of histone H3 at Ser10 in cells.
In Vivo	Tubulin inhibitor 11 (Compound 48; 5-10 mg/kg; p.o; once daily) shows robust in vivo antitumor efficacies[1]. Animal Model: Male athymic BALB/c nude mice (18-20 g) injected with DU145, NCI-H1299 or A549R cells[1] Dosage: 5 mg/kg, 10 mg/kg Administration: p.o; once daily Result: Effectively suppressed tumor growth.
References	[1]. Songwen Lin, et al. Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J Med Chem. 2022 Dec 22;65(24):16372-16391.

Molecular Formula	C₂₂H₂₃N₃O₃S
Molecular Weight	409.50
Storage condition	-20°C

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