1192578-27-0
1192578-27-0 structure
- Name: Enoticumab
- Chemical Name: Enoticumab
- CAS Number: 1192578-27-0
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways Stem Cell/Wnt Notch
- Create Date: 2023-02-24 17:44:21
- Modify Date: 2024-04-05 19:59:48
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Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively[1].
| Name | Enoticumab |
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| Description | Enoticumab (REGN421, SAR153192) is an IgG1κ antibody targeting human Dll4. DLL4 is a ligand of the Notch signaling pathway and regulates fatty acid uptake through non-transcriptional regulation of macropinocytosis-dependent long-chain fatty acid uptake. Specific in vivo activity of Enoticumab in an ovarian xenograft model. EGN421 (2.5 mg/kg once weekly) resulted in 86% and 83% tumor growth inhibition in mouse subcutaneous TOV-112D or intraperitoneal A2780 human tumor xenograft models, respectively[1]. |
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| No Any Chemical & Physical Properties |