Shanghai Nianxing Industrial Co., Ltd
China
Product Name: lutikizumab
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Purity: 90.0%
Stocking Period: 10 Day
Contact: Yang

1791411-57-8

1791411-57-8 structure

1791411-57-8 structure

Name: Lutikizumab
Chemical Name: Lutikizumab
CAS Number: 1791411-57-8
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2023-02-20 04:36:11
Modify Date: 2024-01-10 13:17:41
Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis[1].

Name	Lutikizumab

Description	Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology
In Vitro	ABT-981 可同时结合人 IL-α 和 IL-1β 分子[1]。 ABT-981 对 IL-α 和 IL-1β 表现出高度特异性的结合作用相比于其他 IL-1 家族成员[1]。
In Vivo	Lutikizumab (0.0001-1 mg/kg，腹腔注射，1 次) 对 IL-1α 和 IL-1β 诱导的 IL-6 产生有效抑制作用[1]。 Animal Model: Female C57/BL6 mice with IL-1α and IL-1β injection[1] Dosage: 0.0001-1 mg/kg Administration: Intraperitoneal injection, 0.0001-1 mg/kg, once Result: Dose-dependently decreased the murine IL-6 generated by human and cynomolgus IL-1α and IL-1β.
References	[1]. Lacy SE, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7(3):605-19.

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