Lutikizumab

Modify Date: 2024-01-10 13:17:41

Lutikizumab Structure
Lutikizumab structure
Common Name Lutikizumab
CAS Number 1791411-57-8 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Lutikizumab


Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis[1].

 Names

Name Lutikizumab

 Lutikizumab Biological Activity

Description Lutikizumab (ABT-981) is an anti-IL-1α and IL-1β dual variable domain immunoglobulin. Lutikizumab binds and inhibits IL-1α and IL-1β. Lutikizumab can be used for the research of osteoarthritis[1].
Related Catalog
In Vitro ABT-981 可同时结合人 IL-α 和 IL-1β 分子[1]。 ABT-981 对 IL-α 和 IL-1β 表现出高度特异性的结合作用相比于其他 IL-1 家族成员[1]。
In Vivo Lutikizumab (0.0001-1 mg/kg,腹腔注射,1 次) 对 IL-1α 和 IL-1β 诱导的 IL-6 产生有效抑制作用[1]。 Animal Model: Female C57/BL6 mice with IL-1α and IL-1β injection[1] Dosage: 0.0001-1 mg/kg Administration: Intraperitoneal injection, 0.0001-1 mg/kg, once Result: Dose-dependently decreased the murine IL-6 generated by human and cynomolgus IL-1α and IL-1β.
References

[1]. Lacy SE, et al. Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs. 2015;7(3):605-19.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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