2050816-56-1

2050816-56-1 structure
2050816-56-1 structure
  • Name: Ravagalimab
  • Chemical Name: Ravagalimab
  • CAS Number: 2050816-56-1
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Research Areas Inflammation/Immunology
  • Create Date: 2023-02-24 12:39:49
  • Modify Date: 2024-04-11 13:18:20
  • Ravagalimab (ABBV-323) is a CD40 antagonist (EC50: 3.7 nM). Ravagalimab can be used for research of Crohn's disease[1].

Name Ravagalimab
Description Ravagalimab (ABBV-323) is a CD40 antagonist (EC50: 3.7 nM). Ravagalimab can be used for research of Crohn's disease[1].
Related Catalog
Target

CD40:3.7 nM (EC50)

In Vitro Ravagalimab (0-100 nM,2 天) 抑制原代人 B 细胞上的 CD86 上调,EC50 为 0.6 nM[2]。
References

[1]. Argiriadi MA, et al. CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches. BMC Mol Cell Biol. 2019 Aug 5;20(1):29.  

[2]. Yu X, et al. Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity. Cancer Cell. 2020 Jun 8;37(6):850-866.e7.  

No Any Chemical & Physical Properties
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