Ravagalimab

Modify Date: 2024-04-11 13:18:20

Ravagalimab Structure
Ravagalimab structure
Common Name Ravagalimab
CAS Number 2050816-56-1 Molecular Weight N/A
Density N/A Boiling Point N/A
Molecular Formula N/A Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ravagalimab


Ravagalimab (ABBV-323) is a CD40 antagonist (EC50: 3.7 nM). Ravagalimab can be used for research of Crohn's disease[1].

 Names

Name Ravagalimab

 Ravagalimab Biological Activity

Description Ravagalimab (ABBV-323) is a CD40 antagonist (EC50: 3.7 nM). Ravagalimab can be used for research of Crohn's disease[1].
Related Catalog
Target

CD40:3.7 nM (EC50)

In Vitro Ravagalimab (0-100 nM,2 天) 抑制原代人 B 细胞上的 CD86 上调,EC50 为 0.6 nM[2]。
References

[1]. Argiriadi MA, et al. CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches. BMC Mol Cell Biol. 2019 Aug 5;20(1):29.  

[2]. Yu X, et al. Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity. Cancer Cell. 2020 Jun 8;37(6):850-866.e7.  

 Chemical & Physical Properties

No Any Chemical & Physical Properties
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