2705841-53-6

2705841-53-6 structure

Name: 8RK59
Chemical Name: 8RK59
CAS Number: 2705841-53-6
Molecular Formula: C₃₃H₃₉BF₂N₁₀O₂S
Molecular Weight: 688.60
Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
Create Date: 2023-04-19 17:40:10
Modify Date: 2024-04-06 11:18:35
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1].

Name	8RK59

Description	8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
Target	UCHL1 (ubiquitin C-terminal hydrolase L1)[1]
In Vitro	8RK59 (5 μM, 24 h) 仅与野生型 UCHL1 结合，但不与催化失活的 UCHL1 结合，表明探针结合位点是活性位点半胱氨酸[1]。
References	[1]. Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841.

Molecular Formula	C₃₃H₃₉BF₂N₁₀O₂S
Molecular Weight	688.60