8RK59
Modify Date: 2024-04-06 11:18:35
8RK59 structure
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Common Name | 8RK59 | ||
|---|---|---|---|---|
| CAS Number | 2705841-53-6 | Molecular Weight | 688.60 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H39BF2N10O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 8RK598RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1]. |
| Name | 8RK59 |
|---|
| Description | 8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1]. |
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| Related Catalog | |
| Target |
UCHL1 (ubiquitin C-terminal hydrolase L1)[1] |
| In Vitro | 8RK59 (5 μM, 24 h) 仅与野生型 UCHL1 结合，但不与催化失活的 UCHL1 结合，表明探针结合位点是活性位点半胱氨酸[1]。 |
| References |
| Molecular Formula | C33H39BF2N10O2S |
|---|---|
| Molecular Weight | 688.60 |