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1334107-58-2

1334107-58-2 structure

1334107-58-2 structure

Name: Akt1&PKA-IN-1
Chemical Name: Akt1&PKA-IN-1
CAS Number: 1334107-58-2
Molecular Formula: C₂₀H₁₇Cl₂N₃O
Molecular Weight: 386.27
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2023-05-17 17:17:20
Modify Date: 2024-01-11 17:13:14
Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2)[1].

Name	Akt1&PKA-IN-1

Description	Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2)[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Research Areas >> Others Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	PKAa:0.03 μM (IC50) Akt:0.11 μM (IC50) CDK2:9.8 μM (IC50)
References	[1]. Ashton KS, et al. Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5191-6.

Molecular Formula	C₂₀H₁₇Cl₂N₃O
Molecular Weight	386.27

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