Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: Al-438
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

239066-73-0

239066-73-0 structure
239066-73-0 structure
  • Name: Al-438
  • Chemical Name: AL-438
  • CAS Number: 239066-73-0
  • Molecular Formula: C23H25NO2
  • Molecular Weight: 347.45
  • Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
  • Create Date: 2023-04-05 22:24:44
  • Modify Date: 2024-01-16 08:59:41
  • AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].

Name AL-438
Description AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2].
Related Catalog
Target

Ki: 2.5 nM (glucocorticoid receptor)[1]

In Vitro AL-438 (1 µM) 降低 ATDC5 细胞中 LPS 诱导的 IL-6 的生成[1]。 AL-438 (0-1 µM; 1 h+24 h) 抑制 HSKF1501 细胞中 IL-1β (2 ng/ml) 诱导的 IL-6 表达[2]。
In Vivo AL-438 (1, 10, 100 mg/kg; p.o.) 在大鼠体内显示出抗炎活性[2]。 Animal Model: Male Sprague Dawley rats (carrageenan paw edema model)[2] Dosage: 1, 10, 100 mg/kg Administration: P.o. Result: Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay.
References

[1]. Owen HC, et al. The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70.  

[2]. Coghlan MJ, et al. A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects. Mol Endocrinol. 2003 May;17(5):860-9.  

Molecular Formula C23H25NO2
Molecular Weight 347.45