Name | AL-438 |
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Description | AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2]. |
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Related Catalog | |
Target |
Ki: 2.5 nM (glucocorticoid receptor)[1] |
In Vitro | AL-438 (1 µM) 降低 ATDC5 细胞中 LPS 诱导的 IL-6 的生成[1]。 AL-438 (0-1 µM; 1 h+24 h) 抑制 HSKF1501 细胞中 IL-1β (2 ng/ml) 诱导的 IL-6 表达[2]。 |
In Vivo | AL-438 (1, 10, 100 mg/kg; p.o.) 在大鼠体内显示出抗炎活性[2]。 Animal Model: Male Sprague Dawley rats (carrageenan paw edema model)[2] Dosage: 1, 10, 100 mg/kg Administration: P.o. Result: Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay. |
References |
Molecular Formula | C23H25NO2 |
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Molecular Weight | 347.45 |