Al-438
Modify Date: 2024-01-16 08:59:41
Al-438 structure
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Common Name | Al-438 | ||
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| CAS Number | 239066-73-0 | Molecular Weight | 347.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H25NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Al-438AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2]. |
| Name | AL-438 |
|---|
| Description | AL-438 is a potent, selective and orally active glucocorticoid receptor modulator with Kis of 2.5, 1786, 53, 1440, >1000 nM for glucocorticoid receptor, progesterone receptor, mineralocorticoid receptor, androgen receptor, estrogen receptor, respectively. AL-438 shows antiinflammatory activity[1][2]. |
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| Related Catalog | |
| Target |
Ki: 2.5 nM (glucocorticoid receptor)[1] |
| In Vitro | AL-438 (1 µM) 降低 ATDC5 细胞中 LPS 诱导的 IL-6 的生成[1]。 AL-438 (0-1 µM; 1 h+24 h) 抑制 HSKF1501 细胞中 IL-1β (2 ng/ml) 诱导的 IL-6 表达[2]。 |
| In Vivo | AL-438 (1, 10, 100 mg/kg; p.o.) 在大鼠体内显示出抗炎活性[2]。 Animal Model: Male Sprague Dawley rats (carrageenan paw edema model)[2] Dosage: 1, 10, 100 mg/kg Administration: P.o. Result: Showed antiinflammatory activity with ED50 value of 11 mg/kg in acute inflammation assay. |
| References |
| Molecular Formula | C23H25NO2 |
|---|---|
| Molecular Weight | 347.45 |