1708103-69-8

1708103-69-8 structure

Name: ARTD10/PARP10-IN-2
Chemical Name: ARTD10/PARP10-IN-2
CAS Number: 1708103-69-8
Molecular Formula: C₁₂H₁₃N₃O₃
Molecular Weight: 247.25
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2023-04-05 13:47:12
Modify Date: 2024-05-01 22:12:30
ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively[1].

Name	ARTD10/PARP10-IN-2

Description	ARTD10/PARP10-IN-2 (compound 19) is a potent and non-selective PARP inhibitor, targeting to mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1 with IC50s of 2.0 μM, and 9.7 μM, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Inflammation/Immunology Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	ARTD1/PARP1:9.7 μM (IC50) ARTD10/PARP10:2.0 μM (IC50) ARTD8/PARP14:>20 μM (IC50) ARTD7/PARP15:>20 μM (IC50)
References	[1]. Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51.

Molecular Formula	C₁₂H₁₃N₃O₃
Molecular Weight	247.25