890984-26-6

890984-26-6 structure

Name: Curcumin 5-8
Chemical Name: Curcumin 5-8
CAS Number: 890984-26-6
Molecular Formula: C₂₀H₂₁NO₄
Molecular Weight: 339.39
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-04-15 19:14:55
Modify Date: 2024-01-13 20:34:38
Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity[1].

Name	Curcumin 5-8

Description	Curcumin 5-8 (CUR5-8) is a potent and orally active naturally active curcumin (CUR) analog. Curcumin 5-8 inhibits lipid droplet formation. Curcumin 5-8 increases autophagy and inhibits Apoptosis. Curcumin 5-8 improves insulin resistance and insulin sensitivity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease
In Vitro	Curcumin 5-8 (20 µM; 24 h) 降低 AML12 细胞中 PA (palmitic acid (HY-N0830)) 诱导的 SREBP1 表达水平并增加 Bcl2/BAX 表达[1]。 Western Blot Analysis[1] Cell Line: AML12 cells Concentration: 20 µM Incubation Time: 24 h Result: Significantly decreased PA-induced SREBP1 expression levels, increased Bcl2/BAX expression.
In Vivo	Curcumin 5-8 (100 mg/kg; diet; daily for 13 weeks) 改善 HFD (高脂肪饮食) 诱导的肥胖小鼠的胰岛素抵抗和肝脂肪变性[1]。 Animal Model: 6-week-old males, 20 g, C57BL/6 mice[1] Dosage: 100 mg/kg Administration: Diet; daily for 13 weeks Result: Significantly suppressed the increases in the insulin level and HOMA-IR.
References	[1]. Lee ES, et al. Curcumin analog CUR5-8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity. Metabolism. 2020 Feb;103:154015.

Molecular Formula	C₂₀H₂₁NO₄
Molecular Weight	339.39