2734922-78-0

2734922-78-0 structure

Name: HIF-2α-IN-8
Chemical Name: HIF-2α-IN-8
CAS Number: 2734922-78-0
Molecular Formula: C₁₇H₁₁ClF₇N₃O
Molecular Weight: 441.73
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2023-04-07 11:41:37
Modify Date: 2024-04-05 15:16:10
HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].

Name	HIF-2α-IN-8

Description	HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: 9 nM (HIF2α SPA); 37 nM (HIF2α iScript); 246 nM (HIF2α HRE RGA)[1]
In Vivo	HIF-2α-IN-8 (Example 31) (30 mg/kg; p.o.; daily for 21 days) 在小鼠体内显示出抗肿瘤活性[1]。 Animal Model: 6-9 weeks, female nude Crl:NU(NCr)-Foxn1nu-Homozygous mice (786-O mouse model)[1] Dosage: 30 mg/kg Administration: P.o.; started 34 days post tumor inoculation; daily for 21 days Result: Inhibited the tumor growth.
References	[1]. Robin Alec Fairhurst, et al. Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use. WO2021220170A1.

Molecular Formula	C₁₇H₁₁ClF₇N₃O
Molecular Weight	441.73