2230052-97-6

2230052-97-6 structure

2230052-97-6 structure

Name: PKCiota-IN-1
Chemical Name: PKCiota-IN-1
CAS Number: 2230052-97-6
Molecular Formula: C₂₅H₂₂FN₅O
Molecular Weight: 427.47
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2023-04-07 10:49:57
Modify Date: 2024-04-06 10:51:13
PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].

Name	PKCiota-IN-1

Description	PKCiota-IN-1 (compound 51) is a potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.7 nM. PKCiota-IN-1 also inhibits PKC-α and PKC-ε with IC50s of 45 nM and 450 nM, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCι:2.7 nM (IC50) PKCα:45 nM (IC50) PKCε:450 nM (IC50)
References	[1]. Jacek Kwiatkowski, et al. Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors. J Med Chem. 2018 May 24;61(10):4386-4396.

Molecular Formula	C₂₅H₂₂FN₅O
Molecular Weight	427.47