Top Suppliers:I want be here

  • DC Chemicals Limited
  • China
  • Product Name: SPC4061
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

1018108-22-9

1018108-22-9 structure
1018108-22-9 structure
  • Name: SPC4061
  • Chemical Name: SPC4061
  • CAS Number: 1018108-22-9
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
  • Create Date: 2023-04-10 09:35:37
  • Modify Date: 2024-04-09 18:03:04
  • SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2].

Name SPC4061
Description SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2].
Related Catalog
In Vitro SPC4061 降低了处理细胞中 PCSK9 mRNA 的水平[1]。
In Vivo SPC4061 (首先皮下注射 20 mg/kg, 24 小时后在第 7-28 天注射 5 mg/kg; 每周一次, 共 4 周) 导致猴子模型中产生的血清 PCSK9 蛋白水平的显著降低[1]。
References

[1]. Lindholm MW, et al. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates. Mol Ther. 2012 Feb;20(2):376-81.  

[2]. Li Chuan-Yuan, et al. PCSK9 inhibitor compositions and methods for the treatment of cancer associated with PCSK9 expression: World Intellectual Property Organization, WO2020005869 A2 2020-01-02.

No Any Chemical & Physical Properties