Name | SPC4061 |
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Description | SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases[1][2]. |
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Related Catalog | |
In Vitro | SPC4061 降低了处理细胞中 PCSK9 mRNA 的水平[1]。 |
In Vivo | SPC4061 (首先皮下注射 20 mg/kg, 24 小时后在第 7-28 天注射 5 mg/kg; 每周一次, 共 4 周) 导致猴子模型中产生的血清 PCSK9 蛋白水平的显著降低[1]。 |
References |
No Any Chemical & Physical Properties |