1429024-58-7
1429024-58-7 structure
- Name: STL1267
- Chemical Name: STL1267
- CAS Number: 1429024-58-7
- Molecular Formula: C17H11ClN4O
- Molecular Weight: 322.75
- Catalog: Research Areas Cancer
- Create Date: 2023-08-09 16:44:33
- Modify Date: 2024-04-08 09:55:43
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STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1].
| Name | STL1267 |
|---|
| Description | STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1]. |
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| Related Catalog | |
| Target |
Ki: 0.16 µM (REV-ERBα)[1] |
| In Vitro | STL1267 (5 µM; 24 h) 在 HepG2 细胞中降低 BMAL1 的表达并增加 Mtnd1、Mtco1、Vicad、Lcad、Scad、Lkb1、Sirt1、Nampt、Ppargc1a 的基因表达[1]。 Cell Viability Assay[1] Cell Line: HepG2, C2C12 cells Concentration: 0-20 µM Incubation Time: 24 h Result: Showed no adverse effects on cell viability up to the maximum dose examined 20 µM. RT-PCR[1] Cell Line: HepG2 cells Concentration: 5 µM Incubation Time: 24 h Result: Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a. |
| In Vivo | STL1267 (50 mg/kg; i.p.; once) 在小鼠体内有效抑制 BMAL1 的表达[1]。 Animal Model: 6-8 weeks, male C57Bl/6 J mice[1] Dosage: 50 mg/kg Administration: I.p.; once Result: Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration. |
| References |
| Molecular Formula | C17H11ClN4O |
|---|---|
| Molecular Weight | 322.75 |