2413944-70-2

2413944-70-2 structure

Name: USP7-IN-7
Chemical Name: USP7-IN-7
CAS Number: 2413944-70-2
Molecular Formula: C₂₇H₂₈ClN₃O₃S
Molecular Weight: 510.05
Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
Create Date: 2023-04-05 17:43:06
Modify Date: 2024-04-05 18:52:37
USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC50 value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research[1].

Name	USP7-IN-7

Description	USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC50 value ＜10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
In Vitro	USP7-IN-7 (0-1 μM) 对 p53 野生型血液癌细胞系具有细胞毒性，对 M07e，OCI-AML5，MOLM13 和 MM.IS 的 CC50 值分别为 0.2，0.2，0.4 和 0.1 μM[1]。 USP7-IN-7 (0-2 μM) 对 p53 野生型神经母细胞瘤细胞株具有细胞毒性，对 SH-SY5Y，CHP-134 和 NB-1 的 CC50 值分别为 1.9，0.6 和 0.5 μM[1]。 USP7-IN-7 (0-25 μM) 对 p53 突变癌细胞系具有细胞毒性，对 H526，LA-N-2 和 SK-N-DZ 的 CC50 值分别为 0.5，0.2 和 0.2 μM[1]。
References	[1]. Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.

Molecular Formula	C₂₇H₂₈ClN₃O₃S
Molecular Weight	510.05