USP7-IN-7

Modify Date: 2024-04-05 18:52:37

USP7-IN-7 Structure
USP7-IN-7 structure
Common Name USP7-IN-7
CAS Number 2413944-70-2 Molecular Weight 510.05
Density N/A Boiling Point N/A
Molecular Formula C27H28ClN3O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of USP7-IN-7


USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC50 value <10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research[1].

 Names

Name USP7-IN-7

 USP7-IN-7 Biological Activity

Description USP7-IN-7 (compound 124) is a USP7 inhibitor with an IC50 value <10 nM. USP7-IN-7 shows cytotoxicity against p53-mutant cancer cell lines, p53 wild-type blood cancer and neuroblastoma cell lines with low nanomolar values. USP7-IN-7 can be used for cancer research[1].
Related Catalog
In Vitro USP7-IN-7 (0-1 μM) 对 p53 野生型血液癌细胞系具有细胞毒性,对 M07e,OCI-AML5,MOLM13 和 MM.IS 的 CC50 值分别为 0.2,0.2,0.4 和 0.1 μM[1]。 USP7-IN-7 (0-2 μM) 对 p53 野生型神经母细胞瘤细胞株具有细胞毒性,对 SH-SY5Y,CHP-134 和 NB-1 的 CC50 值分别为 1.9,0.6 和 0.5 μM[1]。 USP7-IN-7 (0-25 μM) 对 p53 突变癌细胞系具有细胞毒性,对 H526,LA-N-2 和 SK-N-DZ 的 CC50 值分别为 0.5,0.2 和 0.2 μM[1]。
References

[1]. Biannic, Berenger, et al. UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF. US20200095260. 2019.

 Chemical & Physical Properties

Molecular Formula C27H28ClN3O3S
Molecular Weight 510.05
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