2869954-53-8

2869954-53-8 structure

Name: Werner syndrome RecQ helicase-IN-4
Chemical Name: Werner syndrome RecQ helicase-IN-4
CAS Number: 2869954-53-8
Molecular Formula: C₃₂H₃₃F₃N₈O₅
Molecular Weight: 666.65
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2023-04-05 11:48:46
Modify Date: 2024-01-18 18:54:25
Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity[1].

Name	Werner syndrome RecQ helicase-IN-4

Description	Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	IC50: 0.06 µM (WRN)[1]
In Vitro	Werner syndrome RecQ helicase-IN-4 (example 58) (0-10 µM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.07，>10 µM[1]。 Cell Proliferation Assay[1] Cell Line: SW48, DLD1 WRN-KO cells Concentration: 0-10 µM Incubation Time: 8-20 days Result: Showed antiproliferative activity with GI50s of 0.07, >10 µM for SW48, DLD1 WRN-KO cells, respectively.
In Vivo	Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) 在小鼠体内显示出抗癌活性[1]。 Animal Model: Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)[1] Dosage: 240 mg/kg Administration: P.o.; daily for 18 days Result: Inhibited tumor growth.
References	[1]. Vincent Bordas, et al. Triazolo-pyrimidine analogues for treating diseases connected to the inhibiton of werner syndrome recq helicase (wrn). WO2022249060A1.

Molecular Formula	C₃₂H₃₃F₃N₈O₅
Molecular Weight	666.65