Werner syndrome RecQ helicase-IN-4
Modify Date: 2024-01-18 18:54:25
Werner syndrome RecQ helicase-IN-4 structure
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Common Name | Werner syndrome RecQ helicase-IN-4 | ||
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| CAS Number | 2869954-53-8 | Molecular Weight | 666.65 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H33F3N8O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Werner syndrome RecQ helicase-IN-4Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity[1]. |
| Name | Werner syndrome RecQ helicase-IN-4 |
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| Description | Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity[1]. |
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| Related Catalog | |
| Target |
IC50: 0.06 µM (WRN)[1] |
| In Vitro | Werner syndrome RecQ helicase-IN-4 (example 58) (0-10 µM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.07，>10 µM[1]。 Cell Proliferation Assay[1] Cell Line: SW48, DLD1 WRN-KO cells Concentration: 0-10 µM Incubation Time: 8-20 days Result: Showed antiproliferative activity with GI50s of 0.07, >10 µM for SW48, DLD1 WRN-KO cells, respectively. |
| In Vivo | Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) 在小鼠体内显示出抗癌活性[1]。 Animal Model: Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)[1] Dosage: 240 mg/kg Administration: P.o.; daily for 18 days Result: Inhibited tumor growth. |
| References |
| Molecular Formula | C32H33F3N8O5 |
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| Molecular Weight | 666.65 |