1818885-55-0

1818885-55-0 structure

Name: AR antagonist 1 hydrochloride
Chemical Name: AR antagonist 1 hydrochloride
CAS Number: 1818885-55-0
Molecular Formula: C₁₅H₂₀Cl₂N₂O
Molecular Weight: 315.24
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2023-05-16 14:12:25
Modify Date: 2024-04-03 15:57:10
AR antagonist 1 (compound 29) hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020)[1].

Name	AR antagonist 1 hydrochloride

Description	AR antagonist 1 (compound 29) hydrochloride is a potent androgen receptor (AR) antagonist and binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266 (HY-133020)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase Signaling Pathways >> Others >> Androgen Receptor
In Vitro	AR antagonist 1 (compound 29) hydrochloride 是 ARD-266 靶连接酶的配体。 ARD-266 是一种高效的基于 VHL E3 连接酶的雄激素受体 (AR) PROTAC 降解剂[1]。 AR antagonist 1 与其 E3 连接酶复合物具有微摩尔结合亲和力，可成功用于设计高效的 PROTAC 降解剂[1]。 PROTAC 包含两个不同的配体，通过一个接头连接；一种是E3泛素连接酶的配体，另一种是靶蛋白的配体。 PROTACs 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
References	[1]. Han X, et al. Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands. J Med Chem. 2019 Dec 26;62(24):11218-11231.

Molecular Formula	C₁₅H₂₀Cl₂N₂O
Molecular Weight	315.24