Name | MK-8189 |
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Description | MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1]. |
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Related Catalog | |
Target |
PDE10A:29 pM (Ki) |
In Vivo | MK-8189 (0.25-0.75 mg/kg; po) 以剂量依赖的方式减弱大鼠的运动活动。 Animal Model: Male Wistar-Hannover rats[1] Dosage: 0.25, 0.5, and 0.75 mg/kg Administration: Oral administration Result: Improved identification ability relative to the vector handling animal. |
References |
Molecular Formula | C19H22N6OS |
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Molecular Weight | 382.48 |