MK-8189

Modify Date: 2024-01-18 19:06:50

MK-8189 structure	Common Name	MK-8189
	CAS Number	1424371-93-6	Molecular Weight	382.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₂N₆OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MK-8189

MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1].

Name	MK-8189

Description	MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Neurological Disease
Target	PDE10A:29 pM (Ki)
In Vivo	MK-8189 (0.25-0.75 mg/kg; po) 以剂量依赖的方式减弱大鼠的运动活动。 Animal Model: Male Wistar-Hannover rats[1] Dosage: 0.25, 0.5, and 0.75 mg/kg Administration: Oral administration Result: Improved identification ability relative to the vector handling animal.
References	[1]. Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66(2):1157-1171.

Molecular Formula	C₁₉H₂₂N₆OS
Molecular Weight	382.48