592-95-0

592-95-0 structure

Name: (1E)-4-Isothiocyanato-1-(methylsulfinyl)-1-butene
Chemical Name: Sulforaphene
CAS Number: 592-95-0
Molecular Formula: C₆H₉NOS₂
Molecular Weight: 175.272
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-08-06 18:21:22
Modify Date: 2024-01-05 11:51:59
Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10-4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals[1][2][3][4].

Name	Sulforaphene
Synonyms	4-isothiocyanato-1-(methylsulfinyl)-1-buten S-SULFORAPHENE (1E)-4-Isothiocyanato-1-(methylsulfinyl)-1-butene SULFORAPHENE,L 4-methylsulfinyl-3-butenyl isothiocyanate 1-Butene, 4-isothiocyanato-1-(methylsulfinyl)-, (1E)- RAPHANIN L-SULFORAPHENE L-SULPHORAPHENE 4-Methylsulfinyl-3-butenyl-isothiocyanat (Sulphoraphen) SULFORAPHANE,DL-(SH) sativin

Description	Sulforaphene, isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10-4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR, p-ERK1/2, NF‐κB and other signals[1][2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Kuang P, et al. Separation and purification of sulforaphene from radish seeds using macroporous resin and preparative high-performance liquid chromatography. Food Chem. 2013 Jan 15;136(2):342-7. [2]. Anita M. Brinker, et al. Herbicidal activity of sulforaphene from stock (Matthiola incana). Journal of Chemical Ecology. Vol. 19. No. 10, 1993. [3]. Mondal A, et al. Sulforaphene promotes Bax/Bcl2, MAPK-dependent human gastric cancer AGS cells apoptosis and inhibits migration via EGFR, p-ERK1/2 down-regulation. General Physiology and Biophysics, 27 Nov 2015, 35(1):25-34. [4]. Ren K, et al. Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway. J Biochem Mol Toxicol. 2017 Aug;31(8).

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),357,1982

51598-96-0

592-95-0

Literature: Journal of Agricultural and Food Chemistry, , vol. 56, # 3 p. 875 - 883

28463-24-3

592-95-0

Literature: Journal of Agricultural and Food Chemistry, , vol. 56, # 3 p. 875 - 883

Precursor 2
51598-96-0 28463-24-3
DownStream 0