463-40-1
463-40-1 structure
- Name: Linolenic acid
- Chemical Name: α-linolenic acid
- CAS Number: 463-40-1
- Molecular Formula: C18H30O2
- Molecular Weight: 278.430
- Catalog: Food additive Nutrition supplements Fatty acids
- Create Date: 2018-02-03 08:00:00
- Modify Date: 2026-06-29 17:46:22
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α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].
| Name | α-linolenic acid |
|---|---|
| Synonyms |
Linolensure
linolenic alpha-Linolenicacid 9,12,15-all-cis-Octadecatrienoic acid Linolein,2-mono 2-linoleoyl-sn-glycerol 2-Monolinolein A-linolenic Linolenic acid remainder linoleic acid 2-Glyceryl 9,12-octadecadienoate linoleic acid monoacylglycerol DELTA 9 CIS 12 CIS 15 CIS OCTADECATRIENOIC ACID CIS,CIS,CIS-9,12,15-OCTADECATRIENOIC ACID α-Lnn, cis,cis,cis-9,12,15-Octadecatrienoic acid (9Z,12Z,15Z)-9,12,15-Octadecatrienoic acid cis-9,cis-12,cis-15-octadecatrienoicacid α-linolenic acid (ALA) MFCD00065720 LINOLENIC ACID WITH ALPHA-LINOLENIC ACID 18:3n-3 LINOLENIC ACID(ALA)(SG) LINOLENICACID(FREE) a-Linolenic Acid CIS-9,12,15-ALPHA-LINOLENICACID Linolenic acid, ., remainder linoleic acid octadecatrienoic acid ALPHA-LINOLENICACIDS alpha-linolenic acid 9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z) 9-cis,12-cis,15-cis-Octadecatrienoic acid CIS-ALPHA-LINOLENICACID ALL CIS-9,12,15-OCTADECATRIENOIC ACID a-Linolenic acid (9Z,12Z)-1,3-dihydroxypropan-2-yl octadeca-9,12-dienoate (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid ALFA-LINOLENIC ACID 9,12,15-OCTADECATRIENIC ACID 9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)- (9CI) γ-Liliolenic acid EINECS 207-334-8 Linolenic acid, R (9Z,12Z,15Z)-linolenic acid (Z,Z,Z)-Octadeca-9,12,15-trienoic acid 15-octadecatrienoicacid,(z,z,z)-12 Linolenic acid,α-Lnn, cis,cis,cis-9,12,15-Octadecatrienoic acid C18:3 (ALL CIS-9,12,15) ACID (9Z,12Z,15Z)-Octadeca-9,12,15-trienoic acid γ-lenoleinic acid(GLA) LINOLENIC ACID 9,12-Octadecadienoic acid (Z,Z)-,2-hydroxy-1-(hydroxymethyl)ethyl ester ALPHA-LNN Glyceryl 2-linoleate 9Z,12Z,15Z-octadecatrienic acid 8,11,14-Htadecatriene-1-cboxylic acid LINOLENICACID,PRACTICAL 2-monolinoleoylglycerol 9Z,12Z,15Z-Octadecatrienoic acid 9Z,12Z,15Z-OCTADECATRIENOIC ACID Linolenic acid,., remainder linoleicacid Linolenic acid, remainder isomers 9,12,15-OCTADECATRIENOIC ACID 9,12,15-octadecatrienoic acid (Z,Z,Z)-9,12,15-Octadecatrienoic acid cis,cis,cis-octadeca-9,12,15-trienoicacid LINOLENIC ACID, STANDD FOR α-Lnn (all-Z)-9,12,15-Octadecatrienoic acid 18:3(n-3) OCTADECA-9Z,12Z,15Z-TRIENOIC ACID ALPHA-LINOLENATE 12,15-Octadecatrienoicacid,(Z,Z,Z)-9 C18:3 (9,12,15-cis all) all cis-Delta-9,12,15-octadecatrienoate 2-Linoleoylglycerol LINOLENSAEURE NATUERLICH Industrene acidelinolenique (all-Z)-9,12,15-Octadecatrienoic Acid |
| Description | α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
PI3K Akt |
| In Vitro | α-Linolenic acid converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1]. |
| In Vivo | α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg[1]. α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1]. α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[1]. Animal Model: Mice weighing at 18 ~ 22 g[1] Dosage: 50, 100, 250 mg/kg Administration: For 10 days Result: Completely inhibited collagen- and adrenaline-induced thrombosis at 250 mg/kg. |
| References |
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 443.4±0.0 °C at 760 mmHg |
| Melting Point | -11 °C(lit.) |
| Molecular Formula | C18H30O2 |
| Molecular Weight | 278.430 |
| Flash Point | 275.7±14.4 °C |
| Exact Mass | 278.224579 |
| PSA | 37.30000 |
| LogP | 6.50 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.491 |
| Storage condition | 2-8°C |
| Water Solubility | INSOLUBLE |
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | F;Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| HS Code | 2916190090 |
|
~95%
463-40-1 |
| Literature: Sandri; Viala Synthesis, 1995 , # 3 p. 271 - 275 |
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| Literature: DSM IP ASSETS B.V. Patent: US2012/277772 A1, 2012 ; |
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| Literature: Cheng, Jin-Tang; Li, Yan; He, Juan; Li, Xing-Yao; Wu, Xing-De; Shao, Li-Dong; Dong, Liao-Bin; Deng, Xu; Gao, Xiu; Peng, Li-Yan; Cheng, Xiao; Zhao, Qin-Shi Helvetica Chimica Acta, 2012 , vol. 95, # 7 p. 1158 - 1163 |
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| Literature: Baruah, Putul; Baruah,Nabin C.; Sharma, Ram P.; Baruah, Jogendra N.; Kulanthaivel, Palianappan; Herz, Werner Phytochemistry (Elsevier), 1983 , vol. 22, # 8 p. 1741 - 1744 |
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| Literature: Sashidhara, Koneni V.; Singh, Suriya P.; Misra, Sweta; Gupta, Jyoti; Misra-Bhattacharya, Shailja European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 230 - 235 |
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463-40-1
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| Literature: Erdmann; Bedford Chemische Berichte, 1909 , vol. 42, p. 1333 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1910 , vol. 69, p. 79 |
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463-40-1
463-40-1 |
| Literature: Hazura Monatshefte fuer Chemie, 1887 , vol. 8, p. 267 Full Text Show Details Erdmann; Bedford Chemische Berichte, 1909 , vol. 42, p. 1333 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1910 , vol. 69, p. 79 |
| Precursor 6 | |
|---|---|
| DownStream 10 | |
![N-[2-(3,4-dihydroxyphenyl)ethyl]octadeca-9,12,15-trienamide structure](https://image.chemsrc.com/caspic/238/105955-13-3.png)
| HS Code | 2916190090 |
|---|---|
| Summary | 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0% |