2414056-34-9

2414056-34-9 structure

2414056-34-9 structure

Name: HER2-IN-13
Chemical Name: HER2-IN-13
CAS Number: 2414056-34-9
Molecular Formula: C₂₆H₂₃ClF₂N₈O₃
Molecular Weight: 568.96
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-05-31 15:49:21
Modify Date: 2024-01-10 18:40:38
HER2-IN-13 (Compound 33) is an HER2 inhibitor with an IC50 of 8 nM. HER2-IN-13 also inhibits wt-EGFR with an IC50 of 0.40 μM[1].

Name	HER2-IN-13

Description	HER2-IN-13 (Compound 33) is an HER2 inhibitor with an IC50 of 8 nM. HER2-IN-13 also inhibits wt-EGFR with an IC50 of 0.40 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	HER2:8 nM (IC50) EGFR (WT):0.40 μM (IC50) hERG:13.3 μM (IC50)
In Vitro	HER2-IN-13 (Compound 33) 抑制 hERG 通道，IC50 为 13.3 μM[1]。
References	[1]. Ding Zhou, et al. Quinazoline derivatives as antitumor agents. Patent WO2020057511A1.

Molecular Formula	C₂₆H₂₃ClF₂N₈O₃
Molecular Weight	568.96