2941243-62-3

2941243-62-3 structure
2941243-62-3 structure
  • Name: Anticancer agent 128
  • Chemical Name: Anticancer agent 128
  • CAS Number: 2941243-62-3
  • Molecular Formula: C26H38N4O4
  • Molecular Weight: 470.60
  • Catalog: Signaling Pathways Apoptosis IAP
  • Create Date: 2023-10-07 18:24:43
  • Modify Date: 2024-01-29 18:52:53
  • Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively[1].

Name Anticancer agent 128
Description Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively[1].
Related Catalog
Target

IC50: 27.2 nM (XIAP-BIR3), 16.6 nM (cIAP1-BIR3), and 8.4 nM (cIAP2-BIR3)[1]

References

[1]. Parima Udompholkul, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.  

Molecular Formula C26H38N4O4
Molecular Weight 470.60