Anticancer agent 128

Modify Date: 2024-01-29 18:52:53

Anticancer agent 128 Structure
Anticancer agent 128 structure
 Common Name Anticancer agent 128
CAS Number 2941243-62-3 Molecular Weight 470.60
Density N/A Boiling Point N/A
Molecular Formula C26H38N4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anticancer agent 128


Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively[1].

 Names

Name Anticancer agent 128

 Anticancer agent 128 Biological Activity

Description Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively[1].
Related Catalog
Target

IC50: 27.2 nM (XIAP-BIR3), 16.6 nM (cIAP1-BIR3), and 8.4 nM (cIAP2-BIR3)[1]

References

[1]. Parima Udompholkul, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.  

 Chemical & Physical Properties

Molecular Formula C26H38N4O4
Molecular Weight 470.60
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Chemsrc provides Anticancer agent 128(CAS#:2941243-62-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Anticancer agent 128 are included as well.>> amp version: Anticancer agent 128

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