Name | AZD4877 |
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Description | AZD4877 is another isostere to Ispinesib (HY-50759)and also a kinesin spindle protein (Eg5) inhibitor with IC50 of 2 nM.AZD4877 arrests cell mitosis, leads to the formation of the monopolar spindle phenotype and induces apoptosis. AZD4877 inhibits circulating peripheral blood mononuclear cells (PBMCs) and has anti-cancer activity[1][2][3][4][5]. |
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Related Catalog | |
Target |
IC50: 2 nM (Eg5)[5] |
References |
Molecular Formula | C28H33N5O2S |
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Molecular Weight | 503.66 |