2227279-84-5

2227279-84-5 structure

Name: GSK-3 inhibitor 3
Chemical Name: GSK-3 inhibitor 3
CAS Number: 2227279-84-5
Molecular Formula: C₂₃H₁₅FN₆O
Molecular Weight: 410.40
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2023-10-24 16:53:48
Modify Date: 2024-01-16 19:50:52
GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].

Name	GSK-3 inhibitor 3

Description	GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK-3α:0.35 nM (IC50) GSK-3β:0.25 nM (IC50) CDK2:0.22 μM (IC50) CDK5:1.3 μM (IC50)
References	[1]. Hartz RA, et.al. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J Med Chem. 2023 Jun 8;66(11):7534-7552.

Molecular Formula	C₂₃H₁₅FN₆O
Molecular Weight	410.40