2952532-92-0

2952532-92-0 structure

Name: IRAK4-IN-28
Chemical Name: IRAK4-IN-28
CAS Number: 2952532-92-0
Molecular Formula: C₂₇H₃₁N₉O₃
Molecular Weight: 529.59
Catalog: Signaling Pathways Immunology/Inflammation IRAK
Create Date: 2023-10-20 11:35:35
Modify Date: 2024-01-29 16:20:12
IRAK4-IN-28 (compound 42) is an orally active IRAK4 inhibitor (IC50=8.9 nM). IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases[1].

Name	IRAK4-IN-28

Description	IRAK4-IN-28 (compound 42) is an orally active IRAK4 inhibitor (IC50=8.9 nM). IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> IRAK Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IC50:8.9 nM (IRAK4)[1], IC50:>30 nM (hERG)[1], Kd:0.58 nM (IRAK4)[1], Kd:140 nM (IRAK1)[1]
References	[1]. Yongjin Hao, et al. Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model. Bioorg Chem. 2023 , 137:106584.

Molecular Formula	C₂₇H₃₁N₉O₃
Molecular Weight	529.59