IRAK4-IN-28

Modify Date: 2024-01-29 16:20:12

IRAK4-IN-28 structure	Common Name	IRAK4-IN-28
	CAS Number	2952532-92-0	Molecular Weight	529.59
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₁N₉O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of IRAK4-IN-28

IRAK4-IN-28 (compound 42) is an orally active IRAK4 inhibitor (IC50=8.9 nM). IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases[1].

Name	IRAK4-IN-28

Description	IRAK4-IN-28 (compound 42) is an orally active IRAK4 inhibitor (IC50=8.9 nM). IRAK4-IN-28 has binding affinity for IRAK4 with a Kd of 0.58 nM. IRAK4-IN-28 can be used in the research of inflammation and autoimmune diseases[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> IRAK Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK
Target	IC50:8.9 nM (IRAK4)[1], IC50:>30 nM (hERG)[1], Kd:0.58 nM (IRAK4)[1], Kd:140 nM (IRAK1)[1]
References	[1]. Yongjin Hao, et al. Design, synthesis, evaluation and optimization of potent IRAK4 inhibitors alleviating production of inflammatory cytokines in LPS-induced SIRS model. Bioorg Chem. 2023 , 137:106584.

Molecular Formula	C₂₇H₃₁N₉O₃
Molecular Weight	529.59

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IRAK4-IN-28

Use of IRAK4-IN-28

Names

IRAK4-IN-28 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.